Minireview:

Carmen W. Dessauer

Adenylyl Cyclase–A-kinase Anchoring Protein Complexes: The Next Dimension in cAMP Signaling
Mol Pharmacol 2009 76: 935-941. Published online August 14, 2009; 10.1124/mol.109.059345 [Abstract] [Full Text] [PDF]  

Perspective:

Mark S. Shapiro

An Ion Channel Hypothesis to Explain Divergent Cardiovascular Safety of Cyclooxygenase-2 Inhibitors: The Answer to a Hotly Debated Puzzle?
Mol Pharmacol 2009 76: 942-945. Published online August 4, 2009; 10.1124/mol.109.059683 [Abstract] [Full Text] [PDF] [Related Article]   

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John F. Deeken, Robert W. Robey, Suneet Shukla, Kenneth Steadman, Arup R. Chakraborty, Balasubramanian Poonkuzhali, Erin G. Schuetz, Susan Holbeck, Suresh V. Ambudkar, and Susan E. Bates

Identification of Compounds that Correlate with ABCG2 Transporter Function in the National Cancer Institute Anticancer Drug Screen
Mol Pharmacol 2009 76: 946-956. Published online July 24, 2009; 10.1124/mol.109.056192 [Abstract] [Full Text] [PDF] [Data Supplement]   

Hany A. Omar, Aaron M. Sargeant, Jing-Ru Weng, Dasheng Wang, Samuel K. Kulp, Tushar Patel, and Ching-Shih Chen

Targeting of the Akt-Nuclear Factor-B Signaling Network by [1-(4-Chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a Novel Indole-3-Carbinol Derivative, in a Mouse Model of Hepatocellular Carcinoma
Mol Pharmacol 2009 76: 957-968. Published online August 25, 2009; 10.1124/mol.109.058180 [Abstract] [Full Text] [PDF] [Data Supplement]   

Emma Ito, Kenneth W. Yip, David Katz, Sonali B. Fonseca, David W. Hedley, Sue Chow, G. Wei Xu, Tabitha E. Wood, Carlo Bastianutto, Aaron D. Schimmer, Shana O. Kelley, and Fei-Fei Liu

Potential Use of Cetrimonium Bromide as an Apoptosis-Promoting Anticancer Agent for Head and Neck Cancer
Mol Pharmacol 2009 76: 969-983. Published online August 4, 2009; 10.1124/mol.109.055277 [Abstract] [Full Text] [PDF]  

Sridharan Soundararajan, Li Wang, Vijayalakshmi Sridharan, Weiwei Chen, Nigel Courtenay-Luck, David Jones, Eleanor K. Spicer, and Daniel J. Fernandes

Plasma Membrane Nucleolin Is a Receptor for the Anticancer Aptamer AS1411 in MV4-11 Leukemia Cells
Mol Pharmacol 2009 76: 984-991. Published online August 5, 2009; 10.1124/mol.109.055947 [Abstract] [Full Text] [PDF] [Data Supplement]   

Donald Beqollari, Matthew J. Betzenhauser, and Paul J. Kammermeier

Altered G-Protein Coupling in an mGluR6 Point Mutant Associated with Congenital Stationary Night Blindness
Mol Pharmacol 2009 76: 992-997. Published online August 7, 2009; 10.1124/mol.109.058628 [Abstract] [Full Text] [PDF] [Data Supplement]   

Sergio Anguissola, Barbara Köhler, Robert O'Byrne, Heiko Düssmann, Mary D. Cannon, Frank E. Murray, Caoimhin G. Concannon, Markus Rehm, Donat Kögel, and Jochen H. M. Prehn

Bid and Calpains Cooperate to Trigger Oxaliplatin-Induced Apoptosis of Cervical Carcinoma HeLa Cells
Mol Pharmacol 2009 76: 998-1010. Published online August 27, 2009; 10.1124/mol.109.058156 [Abstract] [Full Text] [PDF] [Data Supplement]   

Haoming Zhang, Hsia-lien Lin, Vyvyca J. Walker, Djemel Hamdane, and Paul F. Hollenberg

tert-Butylphenylacetylene Is a Potent Mechanism-Based Inactivator of Cytochrome P450 2B4: Inhibition of Cytochrome P450 Catalysis by Steric Hindrance
Mol Pharmacol 2009 76: 1011-1018. Published online August 31, 2009; 10.1124/mol.109.059808 [Abstract] [Full Text] [PDF]  

Karl-Friedrich Deml, Silke Beermann, Detlef Neumann, Andrea Strasser, and Roland Seifert

Interactions of Histamine H₁-Receptor Agonists and Antagonists with the Human Histamine H₄-Receptor
Mol Pharmacol 2009 76: 1019-1030. Published online August 31, 2009; 10.1124/mol.109.058651 [Abstract] [Full Text] [PDF]  

Peter H. Bui and Oliver Hankinson

Functional Characterization of Human Cytochrome P450 2S1 Using a Synthetic Gene-Expressed Protein in Escherichia coli
Mol Pharmacol 2009 76: 1031-1043. Published online August 27, 2009; 10.1124/mol.109.057752 [Abstract] [Full Text] [PDF] [Data Supplement]   

Peter H. Bui, Erin L. Hsu, and Oliver Hankinson

Fatty Acid Hydroperoxides Support Cytochrome P450 2S1-Mediated Bioactivation of Benzo[a]pyrene-7,8-dihydrodiol
Mol Pharmacol 2009 76: 1044-1052. Published online August 27, 2009; 10.1124/mol.109.057760 [Abstract] [Full Text] [PDF]  

Lioubov I. Brueggemann, Alexander R. Mackie, Bharath K. Mani, Leanne L. Cribbs, and Kenneth L. Byron

Differential Effects of Selective Cyclooxygenase-2 Inhibitors on Vascular Smooth Muscle Ion Channels May Account for Differences in Cardiovascular Risk Profiles
Mol Pharmacol 2009 76: 1053-1061. Published online July 15, 2009; 10.1124/mol.109.057844 [Abstract] [Full Text] [PDF] [Data Supplement]   

Jyrki J. Eloranta, Christian Hiller, Stephanie Häusler, Bruno Stieger, and Gerd A. Kullak-Ublick

Vitamin D₃ and Its Nuclear Receptor Increase the Expression and Activity of the Human Proton-Coupled Folate Transporter
Mol Pharmacol 2009 76: 1062-1071. Published online August 7, 2009; 10.1124/mol.109.055392 [Abstract] [Full Text] [PDF]  

Qiang Li, David L. Bartlett, Michael C. Gorry, Mark E. O'Malley, and Z. Sheng Guo

Three Epigenetic Drugs Up-Regulate Homeobox Gene Rhox5 in Cancer Cells through Overlapping and Distinct Molecular Mechanisms
Mol Pharmacol 2009 76: 1072-1081. Published online August 13, 2009; 10.1124/mol.109.056291 [Abstract] [Full Text] [PDF] [Data Supplement]   

John A. Allen, Jiang Z. Yu, Rahul H. Dave, Anushree Bhatnagar, Bryan L. Roth, and Mark M. Rasenick

Caveolin-1 and Lipid Microdomains Regulate G_s Trafficking and Attenuate G_s/Adenylyl Cyclase Signaling
Mol Pharmacol 2009 76: 1082-1093. Published online August 20, 2009; 10.1124/mol.109.060160 [Abstract] [Full Text] [PDF]  

L. Michelle Lewis, Gautam Bhave, Brian A. Chauder, Sreedatta Banerjee, Katharina A. Lornsen, Rey Redha, Katherine Fallen, Craig W. Lindsley, C. David Weaver, and Jerod S. Denton

High-Throughput Screening Reveals a Small-Molecule Inhibitor of the Renal Outer Medullary Potassium Channel and Kir7.1
Mol Pharmacol 2009 76: 1094-1103. Published online August 25, 2009; 10.1124/mol.109.059840 [Abstract] [Full Text] [PDF]  

Amanda K. Riffel, Eric Schuenemann, and Carrie A. Vyhlidal

Regulation of the CYP3A4 and CYP3A7 Promoters by Members of the Nuclear Factor I Transcription Factor Family
Mol Pharmacol 2009 76: 1104-1114. Published online August 25, 2009; 10.1124/mol.109.055699 [Abstract] [Full Text] [PDF]  

Andreas Zeller, M. Verena Wenzl, Matteo Beretta, Heike Stessel, Michael Russwurm, Doris Koesling, Kurt Schmidt, and Bernd Mayer

Mechanisms Underlying Activation of Soluble Guanylate Cyclase by the Nitroxyl Donor Angeli's Salt
Mol Pharmacol 2009 76: 1115-1122. Published online August 31, 2009; 10.1124/mol.109.059915 [Abstract] [Full Text] [PDF] [Data Supplement]   

Lisa A. Vuchak, Oxana M. Tsygankova, Gregory V. Prendergast, and Judy L. Meinkoth

Protein Kinase A and B-Raf Mediate Extracellular Signal-Regulated Kinase Activation by Thyrotropin
Mol Pharmacol 2009 76: 1123-1129. Published online August 31, 2009; 10.1124/mol.109.060129 [Abstract] [Full Text] [PDF]  

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