5 November 2009

Geza Berecki, Leonid Motin, Alison Haythornthwaite, Simone Vink, Paramjit Bansal, Roger Drinkwater, Ching I Wang, Melissa Moretta, Richard J Lewis, Paul F Alewood, MacDonald J Christie, and David J Adams

ANALGESIC -CONOTOXINS CVIE AND CVIF SELECTIVELY AND VOLTAGE DEPENDENTLY BLOCK RECOMBINANT AND NATIVE N-TYPE CALCIUM CHANNELS
Published November 5, 2009; doi:10.1124/mol.109.058834 [Abstract] [PDF]  

4 November 2009

Yuanyuan Zhang, Tianyong Zhao, Wei Li, and Mary Vore

The 5'-untranslated region of multidrug resistance associated protein 2 (MRP2; ABCC2) regulates downstream open reading frame expression through translational regulation
Published November 4, 2009; doi:10.1124/mol.109.058982 [Abstract] [PDF]  

3 November 2009

Naresh Kumar, Laura A Solt, juliana J Conkright, Yongjun Wang, Monica A Istrate, Scott A Busby, Ruben Garcia-Ordonez, Thomas P Burris, and Patrick R Griffin

The benzenesulfoamide T0901317 is a novel ROR/ Inverse Agonist
Published November 3, 2009; doi:10.1124/mol.109.060905 [Abstract] [PDF]  

2 November 2009

Suzanne Tay, Leslie Dickmann, Vaishali Dixit, and Nina Isoherranen

A Comparison of the Role of PPAR and RAR on CYP26 Regulation
Published November 2, 2009; doi:10.1124/mol.109.059071 [Abstract] [PDF]  

30 October 2009

Mohamed Aittaleb, Cassandra A Boguth, and John J G Tesmer

STRUCTURE AND FUNCTION OF HETEROTRIMERIC G PROTEIN-REGULATED RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS
Published October 30, 2009; doi:10.1124/mol.109.061234 [Abstract] [PDF]  

28 October 2009

Haitao You, Christophe Altier, and Gerald W Zamponi

CCR2 receptor ligands inhibit Cav3.2 T-type calcium channels
Published October 28, 2009; doi:10.1124/mol.109.059022 [Abstract] [PDF]  

26 October 2009

Yutaro Obara and Norimichi Nakahata

The signaling pathway leading to ERK5 activation via G-proteins and ERK5-dependent neurotrophic effects
Published October 26, 2009; doi:10.1124/mol.109.060236 [Abstract] [PDF]  

23 October 2009

Hui Zheng, Yan Zeng, Xiaoxiao Zhang, Ji Chu, Horace H. Loh, and Ping-Yee Law

µ-Opioid Receptor Agonists Differentially Regulate the Expression of miR-190 and NeuroD
Published October 23, 2009; doi:10.1124/mol.109.060848 [Abstract] [PDF]  

Alan Chu, Jeremy S Caldwell, and Yu Alice Chen

Identification and Characterization of a Small Molecule Antagonist of Human VPAC₂ Receptor
Published October 23, 2009; doi:10.1124/mol.109.060137 [Abstract] [PDF]  

21 October 2009

Pavle M Joksovic, WonJoo Choe, Michael T Nelson, Peihan Orestes, Barbara C Brimelow, and Slobodan M Todorovic

Mechanisms of inhibition of T-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase C pathway
Published October 21, 2009; doi:10.1124/mol.109.059931 [Abstract] [PDF]  

Marcel P. Goldschen-Ohm, David A. Wagner, Steven Petrou, and Mathew V. Jones

An epilepsy-related region in the GABA_A receptor mediates long-distance effects on GABA and benzodiazepine binding sites.
Published October 21, 2009; doi:10.1124/mol.109.058289 [Abstract] [PDF] [Data Supplement]  

20 October 2009

Pia Kotokorpi, Nicolas Venteclef, Ewa Ellis, Jan-Ake Gustafsson, and Agneta Mode

The human ADFP gene is a direct LXR target gene and differentially regulated by synthetic LXR ligands.
Published October 20, 2009; doi:10.1124/mol.109.059063 [Abstract] [PDF]  

Sreevidya Aluvila, Jiakang Sun, David H.T. Harrison, D. Eric Walters, and Ronald S Kaplan

Inhibitors of the Mitochondrial Citrate Transport Protein: Validation of the Role of Substrate Binding Residues and Discovery of the First Purely Competitive Inhibitor
Published October 20, 2009; doi:10.1124/mol.109.058750 [Abstract] [PDF] [Data Supplement]  

16 October 2009

Shaun P. Brothers, S. Adrian Saldanha, Timothy P. Spicer, Michael Cameron, Becky A. Mercer, Peter Chase, Patricia McDonald, Claes Wahlestedt, and Peter S. Hodder

Selective and Brain Penetrant Neuropeptide Y Y2 Receptor Antagonists Discovered by Whole-Cell High Throughput Screening
Published October 16, 2009; doi:10.1124/mol.109.058677 [Abstract] [PDF] [Data Supplement]  

Brian D Hudson, Terence E Hebert, and Melanie EM Kelly

Ligand and Heterodimer Directed Signaling of the CB₁ Cannabinoid Receptor
Published October 16, 2009; doi:10.1124/mol.109.060251 [Abstract] [PDF]  

14 October 2009

Jong-Ho Lee, Hexiu Jin, Hye-Eun Shim, Ha-Neui Kim, Hyunil Ha, and Zang Hee Lee

Epigallocatechin-3-gallate inhibits osteoclastogenesis by down-regulating c-Fos expression and suppressing the NF-B signal
Published October 14, 2009; doi:10.1124/mol.109.057877 [Abstract] [PDF] [Data Supplement]  

6 October 2009

Lukmanee Tradtrantip, Wan Namkung, and Alan S. Verkman

CROFELEMER, AN ANTI-SECRETORY ANTIDIARRHEAL PROANTHOCYANIDIN OLIGOMER EXTRACTED FROM CROTON LECHLERI, TARGETS TWO DISTINCT INTESTINAL CHLORIDE CHANNELS
Published October 6, 2009; doi:10.1124/mol.109.061051 [Abstract] [PDF]  

5 October 2009

Aaron C. Gerlach, Sally J. Stoehr, and Neil A. Castle

Pharmacological Removal of hERG Potassium Channel Inactivation by ICA-105574
Published October 5, 2009; doi:10.1124/mol.109.059543 [Abstract] [PDF]  

Azahel Rangel, Sergio Sanchez-Armass, and Ulises Meza

Protein kinase C-mediated inhibition of recombinant T-type Ca _V 3.2 channels by neurokinin 1 receptors
Published October 5, 2009; doi:10.1124/mol.109.058727 [Abstract] [PDF]  

30 September 2009

Hasan Irier, Yi Quan, Justin Yoo, and Ray Dingledine

Control of GluR2 translational initiation by its alternative 3^'UTRs
Published September 30, 2009; doi:10.1124/mol.109.060343 [Abstract] [PDF] [Data Supplement]  

28 September 2009

Xiaoqing He and Qiang Ma

NRF2 CYSTEINE RESIDUES ARE CRITICAL FOR OXIDANT/ELECTROPHILE-SENSING, KEAP1-DEPENDENT UBIQUITINATION-PROTEASOMAL DEGRADATION, AND TRANSCRIPTION ACTIVATION
Published September 28, 2009; doi:10.1124/mol.109.058453 [Abstract] [PDF]  

Yoshitake Cho, Mitsuhide Noshiro, Mihwa Choi, Kentaro Morita, Takeshi Kawamoto, Katsumi Fujimoto, Yukio Kato, and Makoto Makishima

The Basic Helix-loop-helix Proteins DEC1 and DEC2 Function as Corepressors of Retinoid X Receptors
Published September 28, 2009; doi:10.1124/mol.109.057000 [Abstract] [PDF]  

Nikhil G Thaker, Fang Zhang, Peter R. McDonald, Tong Ying Shun, Michael D Lewen, Ian F. Pollack, and John S. Lazo

Identification of Survival Genes in Human Glioblastoma Cells Using siRNA Screening
Published September 28, 2009; doi:10.1124/mol.109.058024 [Abstract] [PDF] [Data Supplement]  

25 September 2009

Rachna Sadana, Nathan Dascal, and Carmen W Dessauer

N-terminus of Type 5 Adenylyl Cyclase Scaffolds Gs Heterotrimer
Published September 25, 2009; doi:10.1124/mol.109.058370 [Abstract] [PDF] [Data Supplement]  

24 September 2009

Lu Wang, Yan Shen, Ran Song, Yang Sun, Jianliang Xu, and Qiang Xu

An Anticancer Effect of Curcumin Mediated by Down-regulating PRL-3 Expression on Highly Metastatic Melanoma Cells
Published September 24, 2009; doi:10.1124/mol.109.059105 [Abstract] [PDF] [Data Supplement]  

Zuzana Saidak, Michel Brazier, Said Kamel, and Romuald Mentaverri

Agonists and allosteric modulators of the Calcium Sensing Receptor and their therapeutic applications
Published September 24, 2009; doi:10.1124/mol.109.058784 [Abstract] [PDF]  

21 September 2009

Alexander R. Moise, Susana Alvarez, Marta Dominguez, Rosana Alvarez, Marcin Golczak, Glen P. Lobo, Johannes von Lintig, Angel R. de Lera, and Krzysztof Palczewski

ACTIVATION OF RETINOIC ACID RECEPTORS BY DIHYDRORETINOIDS
Published September 21, 2009; doi:10.1124/mol.109.060038 [Abstract] [PDF] [Data Supplement]  

Madhuchhanda Mandal and Zhen Yan

PIP₂ Regulation of NMDA Receptor Channels in Cortical Neurons
Published September 21, 2009; doi:10.1124/mol.109.058701 [Abstract] [PDF]  

18 September 2009

Keith J Miller, Ginger Y Wu, Jeffrey G Varnes, Paul Levesque, Julia Li, Danshi Li, Jeffrey A Robl, Karen A Rossi, and Dean A Wacker

Position 5.46 of the serotonin 5-HT_2A receptor contributes to a species-dependent variation for the 5-HT_2C agonist (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one: impact on selectivity and toxicological evaluation
Published September 18, 2009; doi:10.1124/mol.109.059204 [Abstract] [PDF] [Data Supplement]  

Alex Straiker, Sherry Shu-Jung Hu, Jonathan Long, Andy Arnold, Jim Wager-Miller, Benjamin F Cravatt, and Ken Mackie

Monoacyl glycerol lipase (MGL) limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation (DSE) in autaptic hippocampal neurons
Published September 18, 2009; doi:10.1124/mol.109.059030 [Abstract] [PDF]  

16 September 2009

Rhonda L. Carter, Ingrid P. Fricks, Matthew O. Barrett, Lauren E. Burianek, Yixing Zhou, Hyojin Ko, Arijit Das, Kenneth A. Jacobson, Eduardo R. Lazarowski, and T. Kendall Harden

Quantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y₁₄ receptor
Published September 16, 2009; doi:10.1124/mol.109.058578 [Abstract] [PDF]  

15 September 2009

Ju-Chi Liu, Cheng-Hsien Chen, Jin-Jer Chen, and Tzu-Hurng Cheng

Urotensin II induces rat cardiomyocyte hypertrophy via the transient oxidization of Src homology 2-containing tyrosine phosphatase and transactivation of epidermal growth factor receptor
Published September 15, 2009; doi:10.1124/mol.109.058297 [Abstract] [PDF]  

Laura Milan-Lobo, Ingrid Gsandtner, Erwin Gaubitzer, Dominik Runzler, Florian Buchmayer, Gottfried Kohler, Antonello Bonci, Michael Freissmuth, and Harald Sitte

Subtype-specific Differences in CRF Receptor Complexes Detected by Fluorescence Spectroscopy
Published September 15, 2009; doi:10.1124/mol.109.059139 [Abstract] [PDF]  

14 September 2009

Sabine Depauw, Thomas Gaslonde, Stephane Leonce, Laurence Kraus-Berthier, William Laine, Gaelle Lenglet, Angele Chiaroni, Bruno Pfeiffer, Christian Bailly, Sylvie Michel, Francois Tillequin, Alain Pierre, and Marie-Helene David-Cordonnier

Influence of the stereoisomeric position of the reactive acetate groups of the benzo[b]acronycine derivative S23906-1 on its DNA alkylation, helix opening, cytotoxic and anti-tumor activities
Published September 14, 2009; doi:10.1124/mol.109.057554 [Abstract] [PDF] [Data Supplement]  

Tengis S Pavlov, Vladislav Levchenko, Alexey V Karpushev, Alain Vandewalle, and Alexander Staruschenko

PPAR antagonists decrease Na⁺ transport via the epithelial Na⁺ channel (ENaC)
Published September 14, 2009; doi:10.1124/mol.109.056911 [Abstract] [PDF]  

11 September 2009

Serife Cankurtaran-Sayar, Kemal Sayar, and Mehmet Ugur

P2X7 RECEPTOR ACTIVATES MULTIPLE SELECTIVE DYE PERMEATION PATHWAYS IN RAW 264.7 AND HEK-293 CELLS
Published September 11, 2009; doi:10.1124/mol.109.059923 [Abstract] [PDF] [Data Supplement]  

9 September 2009

Susanne Reiner, Nicole Ziegler, Cathrine Leon, Kristina Lorenz, Kathrin von Hayn, Christian Gachet, Martin J Lohse, and Carsten Hoffmann

-ARRESTIN-2 INTERACTION AND INTERNALIZATION OF THE HUMAN P2Y₁-RECEPTOR ARE DEPENDENT ON C-TERMINAL PHOSPHORLAYTION SITES
Published September 9, 2009; doi:10.1124/mol.109.060467 [Abstract] [PDF]  

Shary N Shelton, Mary E Shawgo, Shawna B Comer, Yuanming Lu, Alison C Donnelly, Kristen Szabla, Mehmet Tanol, George A Vielhauer, Roger A Rajewski, Robert L Matts, Brian S J Blagg, and John D Robertson

KU135, a Novel Novobiocin-derived C-terminal Inhibitor of Hsp90, Exerts Potent Antiproliferative Effects in Human Leukemic Cells
Published September 9, 2009; doi:10.1124/mol.109.058545 [Abstract] [PDF]  

Ligong Chen, Gregory D Salinas, and Xiaohua Li

Regulation of Serotonin 1B Receptor by Glycogen Synthase Kinase-3
Published September 9, 2009; doi:10.1124/mol.109.056994 [Abstract] [PDF]  

8 September 2009

Sophie J Bradley, Jeannette M. Watson, and R.A. John Challiss

Effects of Positive Allosteric Modulators on Single Cell Oscillatory Ca²⁺ Signaling Initiated by the Type 5 Metabotropic Glutamate (mGlu5) Receptor
Published September 8, 2009; doi:10.1124/mol.109.059170 [Abstract] [PDF]  

4 September 2009

Haiyan Liu, Judith A. Enyeart, and John J. Enyeart

N6-substituted cAMP Analogs Inhibit bTREK-1 K⁺ Channels and Stimulate Cortisol Secretion by a PKA-Independent Mechanism
Published September 4, 2009; doi:10.1124/mol.109.057075 [Abstract] [PDF]  

2 September 2009

Susan Oldfield, Jane M Hancock, Angharad Mason, Sally A Hobson, David Wynick, Eamonn Kelly, Andrew D Randall, and Neil V Marrion

Receptor-mediated suppression of potassium currents requires co-localization within lipid rafts.
Published September 2, 2009; doi:10.1124/mol.109.058008 [Abstract] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.