20 August 2008

Ling-Chan Kung, Samuel H.H. Chan, Kay L.H. Wu, Chen-Chun Ou, Ming-Hon Tai, and Julie Y.H. Chan

Mitochondrial Respiratory Enzyme Complexes in Rostral Ventrolateral Medulla as Cellular Targets of Nitric Oxide and Superoxide Interaction in the Antagonism of Antihypertensive Action of eNOS Transgene
Published August 20, 2008; doi: 10.1124/mol.108.048793 [Abstract] [PDF] [Data Supplement]  

19 August 2008

Pedro J Gonzalez-Cabrera, Euijung Jo, M Germana Sanna, Steven Brown, Nora Leaf, David Marsolais, Marie-Therese Schaeffer, Jackie Chapman, Michael Cameron, Miguel Guerrero, Edward Roberts, and Hugh Rosen

Full pharmacological efficacy of a novel S1P₁ agonist that does not require S1P-like head-group interactions
Published August 19, 2008; doi: 10.1124/mol.108.049783 [Abstract] [PDF] [Data Supplement]  

David J Nicholls, Nick P Tomkinson, Katherine E Wiley, Anne Brammall, Lorna Bowers, Caroline Grahames, Alasdair Gaw, Premji Meghani, Philip Shelton, Tracy J Wright, and Philip R Mallinder

Identification of a Putative Intracellular Allosteric Antagonist Binding-Site in the CXC Chemokine Receptors 1 and 2
Published August 19, 2008; doi: 10.1124/mol.107.044610 [Abstract] [PDF] [Data Supplement]  

Francesca Binda, Concetta Dipace, Erica Bowton, Sabrina D Robertson, Brandon J Lute, Jacob U Fog, Minjia Zhang, Namita Sen, Roger J Colbran, Margaret E Gnegy, Ulrik Gether, Jonathan A Javitch, Kevin Erreger, and Aurelio Galli

Syntaxin1A Interaction with the Dopamine Transporter Promotes Amphetamine-Induced Dopamine Efflux
Published August 19, 2008; doi: 10.1124/mol.108.048447 [Abstract] [PDF]  

14 August 2008

Amit Roy, Agneyo Ganguly, Somdeb BoseDasgupta, Benu Brata Das, Churala Pal, Parasuraman Jaisankar, and Hemanta K. Majumder

Mitochondria dependent ROS-mediated programmed cell death (PCD) induced by 3,3'-Diindolylmethane (DIM) through Inhibition of FoF1-ATP synthase in unicellular protozoan parasite Leishmania donovani
Published August 14, 2008; doi: 10.1124/mol.108.050161 [Abstract] [PDF] [Data Supplement]  

Vania De Arcangelis, Dagoberto Soto, and Yang Xiang

Phosphodieasterase 4 and phosphatase 2A differentially regulate cAMP/PKA signaling for cardiac myocyte contraction under stimulation of ₁ adrenergic receptor
Published August 14, 2008; doi: 10.1124/mol.108.049718 [Abstract] [PDF] [Data Supplement]  

Juan F. Lopez-Gimenez, M. Teresa Vilaro, and Graeme Milligan

Morphine desensitization, internalization and down-regulation of the mu opioid receptor is facilitated by serotonin 5-HT_2A receptor co-activation
Published August 14, 2008; doi: 10.1124/mol.108.048272 [Abstract] [PDF] [Data Supplement]  

Bruno P Guiard, Mostafa El Mansari, and Pierre Blier

Crosstalk between dopaminergic and noradrenergic systems in the rat ventral tegmental area, locus coeruleus, and dorsal hippocampus
Published August 14, 2008; doi: 10.1124/mol.108.048033 [Abstract] [PDF]  

13 August 2008

Markus Rieck, Wolfgang Meissner, Simone Ries, Sabine Muller-Brusselbach, and Rolf Muller

Ligand-mediated regulation of PPAR/: a comparative analysis of PPAR-selective agonists and all-trans retinoic acid (atRA)
Published August 13, 2008; doi: 10.1124/mol.108.050625 [Abstract] [PDF]  

Michael G. Borland, Jennifer E. Foreman, Elizabeth E. Girroir, Reza Zolfaghari, Arun K. Sharma, Shantu M. Amin, Frank J. Gonzalez, A. Catharine Ross, and Jeffrey M. Peters

Ligand Activation of Peroxisome Proliferator-Activated Receptor-/ (PPAR/) Inhibits Cell Proliferation in Human HaCaT Keratinocytes
Published August 13, 2008; doi: 10.1124/mol.108.050609 [Abstract] [PDF] [Data Supplement]  

Mark J Perrin, Philip W Kuchel, Terence J Campbell, and Jamie I Vandenberg

Drug binding to the inactivated state is necessary but not sufficient for high affinity binding to hERG channels
Published August 13, 2008; doi: 10.1124/mol.108.049056 [Abstract] [PDF] [Data Supplement]  

8 August 2008

Paul Cornett, Jose Matta, and Gerard Ahern

General Anesthetics Sensitize the Capsaicin Receptor TRPV1
Published August 8, 2008; doi: 10.1124/mol.108.049684 [Abstract] [PDF]  

7 August 2008

Xing Yin, Bo Li, Hung-dar Chen, and Kevin J. Catt

Differential Signaling Pathways in Angiotensin II- and EGF-stimulated Hepatic C9 Cells
Published August 7, 2008; doi: 10.1124/mol.108.048504 [Abstract] [PDF]  

Jillian G Baker, Richard GW Proudman, Nicola C Hawley, Peter M Fischer, and Stephen J Hill

Role of key transmembrane residues in agonist and antagonist actions at the two conformations of the human 1-adrenoceptor
Published August 7, 2008; doi: 10.1124/mol.108.048371 [Abstract] [PDF] [Data Supplement]  

6 August 2008

Alexander R Mackie and Kenneth L Byron

Cardiovascular KCNQ (Kv7) Potassium Channels: Physiological Regulators and New Targets for Therapeutic Intervention
Published August 6, 2008; doi: 10.1124/mol.108.049825 [Abstract] [PDF]  

Myong-Hee Sung, Lorena Bagain, Zhong Chen, Tatiana Karpova, Xinping Yang, Christopher Silvin, Ty Voss, James McNally, Carter Van Waes, and Gordon L Hager

Dynamic Effect of Bortezomib on NF-B Activity and Gene Expression in Tumor Cells
Published August 6, 2008; doi: 10.1124/mol.108.049114 [Abstract] [PDF] [Data Supplement]  

Masaaki Sato, Dana S Hutchinson, Bronwyn A Evans, and Roger J. Summers

The ₃-adrenoceptor agonist L755507 and antagonist L748337 activate different signalling pathways in CHO-K1 cells stably expressing the human ₃-adrenoceptor
Published August 6, 2008; doi: 10.1124/mol.108.046979 [Abstract] [PDF]  

Benjamin K Lau and Christopher W Vaughan

Muscarinic modulation of synaptic transmission via endocannabinoid signalling in the rat midbrain periaqueductal grey
Published August 6, 2008; doi: 10.1124/mol.108.045872 [Abstract] [PDF]  

5 August 2008

Angelika Klose, Tobias Huth, and Christian Alzheimer

U73122 Selectively Inhibits Kir3 and BK Channels in a Phospholipase C-Independent Fashion
Published August 5, 2008; doi: 10.1124/mol.108.047837 [Abstract] [PDF]  

4 August 2008

Jun-Yang Liou, Chia-Ching Wu, Bo-Rui Chen, Linju B. Yen, and Kenneth K. Wu

Nonsteroidal Anti-inflammatory Drugs Induced Endothelial Apoptosis by Perturbing PPAR- Transcriptional Pathway
Published August 4, 2008; doi: 10.1124/mol.108.049569 [Abstract] [PDF]  

Daniel Bertrand, Sonia Bertrand, Steven Cassar, Earl Gubbins, Jinhe Li, and Murali Gopalakrishnan

Positive Allosteric Modulation of the 7 nAChR: Ligand Interactions with Distinct Binding Sites and Evidence for a Prominent Role of the M2-M3 Segment 7 nAChR: Ligand Interactions with Distinct Binding Sites and Evidence for a Prominent Role of the M2-M3 Segment
Published August 4, 2008; doi: 10.1124/mol.107.042820 [Abstract] [PDF]  

1 August 2008

Simone Cardaci, Giuseppe Filomeni, Giuseppe Rotilio, and Maria R Ciriolo

REACTIVE OXYGEN SPECIES MEDIATE p53 ACTIVATION AND APOPTOSIS INDUCED BY SODIUM NITROPRUSSIDE IN SH-SY5Y CELLS
Published August 1, 2008; doi: 10.1124/mol.108.048975 [Abstract] [PDF] [Data Supplement]  

Ghenet K Hagos, Samer O Abdul-Hay, Johan Sohn, Praneeth D Edirisinghe, Zhiqiang Wang, R. Esala P Chandrasena, Qian Li, and Gregory R Thatcher

Anti-inflammatory, antiproliferative, and cytoprotective activity of NO chimera nitrates of use in cancer chemoprevention
Published August 1, 2008; doi: 10.1124/mol.108.046664 [Abstract] [PDF] [Data Supplement]  

31 July 2008

Robert J. Paproski, Amy M. L. Ng, Sylvia Y. M. Yao, Kathryn Graham, James D. Young, and Carol E. Cass

The Role of Human Nucleoside Transporters in Uptake of 3'-Deoxy-3'-Fluorothymidine
Published July 31, 2008; doi: 10.1124/mol.108.048900 [Abstract] [PDF]  

Bernice C Lin, Linh P Nguyen, Jacqueline A Walisser, and Christopher A Bradfield

A Hypomorphic Allele of Aryl-hydrocarbon Receptor-associated-9 Produces a Phenocopy of the Ahr Null
Published July 31, 2008; doi: 10.1124/mol.108.047068 [Abstract] [PDF]  

30 July 2008

Wassana Wijagkanalan, Yuriko Higuchi, Shigeru Kawakami, Mugen Teshima, Hitoshi Sasaki, and Mitsuru Hashida

Enhanced anti-inflammation of inhaled dexamethasone palmitate using mannosylated liposomes in an endotoxin-induced lung inflammation model
Published July 30, 2008; doi: 10.1124/mol.108.050153 [Abstract] [PDF]  

Carine Chavey, Marcus Muhlbauer, Carine Bossard, Ariane Freund, Sebastien Durand, Christian Jorgensen, Christian Jobin, and Gwendal LAZENNEC

Interleukin-8 expression is regulated by histone deacetylases through the NF-B pathway in breast cancer
Published July 30, 2008; doi: 10.1124/mol.108.047332 [Abstract] [PDF] [Data Supplement]  

29 July 2008

Colleen M. Niswender, Kari A. Johnson, C. David Weaver, Carrie K. Jones, Zixiu Xiang, Qingwei Luo, Alice L. Rodriguez, Joy E. Marlo, Tomas de Paulis, Analisa D. Thompson, Emily L. Days, Tasha Nalywajko, Cheryl A. Austin, Michael Baxter Williams, Jennifer E. Ayala, Richard Williams, Craig W. Lindsley, and P. Jeffrey Conn

Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4
Published July 29, 2008; doi: 10.1124/mol.108.049551 [Abstract] [PDF] [Data Supplement]  

Iva Bruhova, Denis B Tikhonov, and Boris S Zhorov

Access and Binding of Local Anesthetics in the Closed Sodium Channel
Published July 29, 2008; doi: 10.1124/mol.108.049759 [Abstract] [PDF] [Data Supplement]  

Yihong Zhang, Naushaba Nayeem, and Tim Green

Mutations to the kainate receptor subunit GluR6 binding pocket that selectively affect domoate binding
Published July 29, 2008; doi: 10.1124/mol.108.048819 [Abstract] [PDF] [Data Supplement]  

24 July 2008

Christopher J. Clarke, J. Michael Guthrie, and Yusuf A. Hannun

Regulation of Neutral Sphingomyelinase-2 (nSMase2) by Tumor Necrosis Factor- involves Protein Kinase C- in Lung Epithelial Cells
Published July 24, 2008; doi: 10.1124/mol.108.046250 [Abstract] [PDF] [Data Supplement]  

22 July 2008

Verawan Uchaipichat, Aleksandra Galetin, J Brian Houston, Peter I Mackenzie, J Andrew Williams, and John O Miners

Kinetic modeling of the interactions between 4-methylumbelliferone, 1-naphthol and zidovudine glucuronidation by UDP-glucuronosyltransferase 2B7 (UGT2B7) provides evidence for multiple substrate binding and effector sites
Published July 22, 2008; doi: 10.1124/mol.108.048645 [Abstract] [PDF]  

17 July 2008

Yeung Ho, Ranmal Samarasinghe, Megan E Knoch, Marcia Lewis, Elias Aizenman, and Donald B DeFranco

Selective Inhibition of MAPK Phosphatases by Zinc Accounts for ERK1/2-dependent Oxidative Neuronal Cell Death
Published July 17, 2008; doi: 10.1124/mol.108.049064 [Abstract] [PDF]  

Jun-Jie Yin, Fang Lao, Jie Meng, Peter P Fu, Yuliang Zhao, Gengmei Xing, XueYun Gao, Baoyun Sun, Paul C Wang, Chunying Chen, and Xing-Jie Liang

Inhibition of Tumor Growth by Endohedral Metallofullerenol Nanoparticles Optimized as Reactive Oxygen Species Scavenger
Published July 17, 2008; doi: 10.1124/mol.108.048348 [Abstract] [PDF] [Data Supplement]  

15 July 2008

Tau Benned-Jensen and Mette M Rosenkilde

Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2 - Analysis of receptor activation in the absence of an agonist
Published July 15, 2008; doi: 10.1124/mol.108.049676 [Abstract] [PDF] [Data Supplement]  

Vindhya Nawaratne, Katie Leach, Nur Suratman, Richard E Loiacono, Christian C Felder, Blaine N Armbruster, Bryan L Roth, Patrick M Sexton, and Arthur Christopoulos

New insights into the function of M₄ muscarinic acetylcholine receptors gained using a novel allosteric modulator and a "designer receptor exclusively activated by a designer drug" (DREADD)
Published July 15, 2008; doi: 10.1124/mol.108.049353 [Abstract] [PDF] [Data Supplement]  

Mary L Garcia-Cazarin, Jennifer L Smith, Daret K St Clair, and Michael T Piascik

The Alpha_1D-Adrenergic Receptor Induces Vascular Smooth Muscle Apoptosis via a p53-Dependent Mechanism
Published July 15, 2008; doi: 10.1124/mol.108.047993 [Abstract] [PDF] [Data Supplement]  

11 July 2008

Namandje N Bumpus and Paul F. Hollenberg

Investigation of the mechanisms underlying the differential effects of the K262R mutation of P450 2B6 on catalytic activity
Published July 11, 2008; doi: 10.1124/mol.108.048637 [Abstract] [PDF]  

Serge Guerreiro, Damien Toulorge, Etienne Hirsch, Marc Marien, Pierre Sokoloff, and Patrick P Michel

Paraxanthine, the Primary Metabolite of Caffeine Provides Protection against Dopaminergic Cell Death via Stimulation of Ryanodine Receptor Channels
Published July 11, 2008; doi: 10.1124/mol.108.048207 [Abstract] [PDF]  

10 July 2008

NATALIA C FERNANDEZ, Federico Monczor, ALBERTO BALDI, Carlos A. Davio, and Carina Shayo

Histamine H2 receptor trafficking: Role of arrestin, dynamin and clathrin in H2r internalization
Published July 10, 2008; doi: 10.1124/mol.108.045336 [Abstract] [PDF]  

9 July 2008

Azza A.K. El-Sheikh, Jeroen J.M.W. van den Heuvel, Elmar Krieger, Frans G.M. Russel, and Jan B. Koenderink

Functional Role of Arginine 375 in Transmembrane Helix 6 of Multidrug Resistance Protein 4 (MRP4/ABCC4)
Published July 9, 2008; doi: 10.1124/mol.107.043661 [Abstract] [PDF]  

8 July 2008

Christine Graf, Martin Klumpp, Michael Habig, Philipp Rovina, Andreas Billich, Thomas Baumruker, Berndt Oberhauser, and Frederic Bornancin

Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor
Published July 8, 2008; doi: 10.1124/mol.108.048652 [Abstract] [PDF] [Data Supplement]  

Seksiri Arttamangkul, Nidia Quillinan, Malcolm Low, Mark vonZastrow, John Pintar, and John T. Williams

Differential Activation and Trafficking of Mu-opioid Receptors in Brain Slices
Published July 8, 2008; doi: 10.1124/mol.108.048512 [Abstract] [PDF]  

David Kowalski, Lakshmi Pendyala, Bertrand Daignan-Fornier, Stephen B Howell, and Ruea-Yea Huang

Disregulation of Purine Nucleotide Biosynthesis Pathways Modulates Cisplatin Cytotoxicity in Saccharomyces cerevisiae
Published July 8, 2008; doi: 10.1124/mol.108.048256 [Abstract] [PDF] [Data Supplement]  

Anja Verhulst, Rachel Sayer, Marc E De Broe, Patrick C D'Haese, and Colin DA Brown

Human proximal tubular epithelium actively secretes but does not retain rosuvastatin
Published July 8, 2008; doi: 10.1124/mol.108.047647 [Abstract] [PDF]  

3 July 2008

Dana Schiefelbein, Oliver Seitz, Itamar Goren, Jan Philipp DiBmann, Helmut Schmidt, Malte Bachmann, Robert Sader, Gerd Geisslinger, Josef Pfeilschifter, and Stefan Frank

Keratinocyte-derived VEGF biosynthesis represents a pleiotropic side effect of PPAR agonist troglitazone but not rosiglitazone and involves activation of p38 MAPK: implications for diabetes-impaired skin repair
Published July 3, 2008; doi: 10.1124/mol.108.049395 [Abstract] [PDF] [Data Supplement]  

Jianliang Zhang, Fenqin Xue, and Yongchang Chang

Structural determinants for antagonist pharmacology that distinguishes the 1 GABA_C receptor from GABA_A receptors
Published July 3, 2008; doi: 10.1124/mol.108.048710 [Abstract] [PDF]  

Masahiko Watabe and Toshio Nakaki

Mitochondrial complex I inhibitor rotenone inhibits and redistributes vesicular monoamine transporter 2 via nitration in human dopaminergic SH-SY5Y cells
Published July 3, 2008; doi: 10.1124/mol.108.048546 [Abstract] [PDF]  

1 July 2008

Naeem R Khawaja, Manon Carre, Herve Kovacic, Marie-Anne Esteve, and Diane Braguer

Patupilone-induced apoptosis is mediated by mitochondrial reactive oxygen species through Bim relocalization to mitochondria
Published July 1, 2008; doi: 10.1124/mol.108.048405 [Abstract] [PDF]  

Tao Qi, George Christopoulos, Richard J Bailey, Arthur Christopoulos, Patrick M. Sexton, and Debbie L Hay

Identification of N-terminal receptor activity-modifying protein residues important for CGRP, adrenomedullin and amylin receptor function
Published July 1, 2008; doi: 10.1124/mol.108.047142 [Abstract] [PDF] [Data Supplement]  

26 June 2008

Terry P Kenakin

Seven Transmembrane Receptors as Nature's Prototype Allosteric Protein:De-emphasizing the Geography of Binding (Relates to article by Redka, et al., Fast Forward 13 Jun 08)
Published June 26, 2008; doi: 10.1124/mol.108.050062 [Abstract] [PDF]  

Xiomara A Perez, Tanuja Bordia, J. Michael McIntosh, Sharon R. Grady, and Maryka Quik

Chronic nicotine treatment differentially regulates striatal 642* and 6(non4)2* nAChR expression and function
Published June 26, 2008; doi: 10.1124/mol.108.048843 [Abstract] [PDF]  

Dharini van der Hoeven, Tina C. Wan, and John A. Auchampach

Activation of the A₃ Adenosine Receptor Suppresses Superoxide Production and Chemotaxis of Mouse Bone Marrow Neutrophils
Published June 26, 2008; doi: 10.1124/mol.108.048066 [Abstract] [PDF]  

Frederick S. Jones, Jie Jing, Anthony H. Stonehouse, Anthony Stevens, and Gerald M. Edelman

Caffeine stimulates cytochrome oxidase expression and activity in the striatum in a sexually-dimorphic manner
Published June 26, 2008; doi: 10.1124/mol.108.046888 [Abstract] [PDF]  

Patrice M. Mich and William A. Horne

Alternative Splicing of the Ca²⁺ Channel 4 Subunit Confers Gabapentin Specificity for Inhibition of Ca_v2.1 Trafficking
Published June 26, 2008; doi: 10.1124/mol.108.045153 [Abstract] [PDF]  

25 June 2008

Sean Ekins, Vladyslav Kholodovych, Ni Ai, Michael Sinz, Joseph Gal, Lajos Gera, William J Welsh, Kenneth Bachmann, and Sridhar Mani

COMPUTATIONAL DISCOVERY OF NOVEL LOW MICROMOLAR HUMAN PREGNANE X RECEPTOR ANTAGONISTS
Published June 25, 2008; doi: 10.1124/mol.108.049437 [Abstract] [PDF] [Data Supplement]  

24 June 2008

David Marsolais, Bumsuk Hahm, Kurt H Edelmann, Kevin B Walsh, Miguel Guerrero, Yosuko Hatta, Yoshihiro Kawaoka, Edward Roberts, Michael B Oldstone, and Hugh Rosen

Local not systemic modulation of dendritic cell S1P receptors in lung blunts virus-specific immune responses to influenza
Published June 24, 2008; doi: 10.1124/mol.108.048769 [Abstract] [PDF] [Data Supplement]  

Federica Fala, William L. Blalock, PierLuigi Tazzari, Alessandra Cappellini, Francesca Chiarini, Giovanni Martinelli, Agostino Tafuri, James A. McCubrey, Lucio Cocco, and Alberto M Martelli

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor, A443654, in T-Acute Lymphoblastic Leukemia
Published June 24, 2008; doi: 10.1124/mol.108.047639 [Abstract] [PDF]  

Andrea L Kasinski, Yuhong Du, Shala L Thomas, Jing Zhao, Shi-Yong Sun, Fadlo R Khuri, Cun-Yu Wang, Mamoru Shoji, Aiming Sun, James P Snyder, Dennis Liotta, and Haian Fu

Inhibition of IKK-NF-B signaling pathway by EF24, a novel monoketone analogue of curcumin
Published June 24, 2008; doi: 10.1124/mol.108.046201 [Abstract] [PDF] [Data Supplement]  

Yi-Lin Chen, Min-Hui Jian, Chai-Ching Lin, Jung-Cheng Kang, Shee-Ping Chen, Po-Cheng Lin, Putzer-Joseph Hung, Jen-Ren Chen, Wen-Liang Chang, Shinn-Zong Lin, and Horng-Jyh Harn

The induction of orphan nuclear receptor Nur77 expression by n-butylenephthalide as pharmaceuticals on hepatocellular carcinoma (HCC) cells therapy
Published June 24, 2008; doi: 10.1124/mol.107.044800 [Abstract] [PDF]  

23 June 2008

Lisa Mathiasen, Daniel M. Dupont, Anni Christensen, Grant E. Blouse, Jan K. Jensen, Ann Gils, Paul J. Declerck, Troels Wind, and Peter A. Andreasen

A Peptide Accelerating the Conversion of Plasminogen Activator Inhibitor-1 to an Inactive Latent State
Published June 23, 2008; doi: 10.1124/mol.108.046417 [Abstract] [PDF]  

13 June 2008

Sailesh Surapureddi, Ritu Rana, Janardan K Reddy, and Joyce A Goldstein

THE COACTIVATOR NCOA6 MEDIATES THE SYNERGISTIC ACTIVATION OF HUMAN CYTOCHROME P-450 2C9 BY THE CONSTITUTIVE ANDROSTANE RECEPTOR AND HEPATIC NUCLEAR FACTOR-4
Published June 13, 2008; doi: 10.1124/mol.108.048983 [Abstract] [PDF]  

Dar'ya S. Redka, Luca F. Pisterzi, and James W. Wells

Binding of Orthosteric Ligands to the Allosteric Site of the M₂ Muscarinic Cholinergic Receptor
Published June 13, 2008; doi: 10.1124/mol.108.048074 [Abstract] [PDF]  

Jianxi Liu, Thirumalini Vaithianathan, Kandiah Manivannan, Abby Parrill, and Alex M Dopico

Ethanol modulates BK_Ca channels by acting as an adjuvant of calcium
Published June 13, 2008; doi: 10.1124/mol.108.048694 [Abstract] [PDF] [Data Supplement]  

12 June 2008

Yun Ge, Jung S. Byun, Paola De Luca, Geraldine Gueron, Quentin Q Li, Idalia M. Yabe, Sara G. Sadiq-Ali, William D Figg, Jesse Quintero, Cynthia M Haggerty, Adriana De Siervi, and Kevin Gardner

Combinatorial anti-leukemic disruption of oxidative homeostasis and mitochondrial stability by the redox reactive thalidomide CPS49 and flavopiridol
Published June 12, 2008; doi: 10.1124/mol.107.040808 [Abstract] [PDF]  

Isamu Aiba, Anwar Hossain, and Macus Tien Kuo

Elevated GSH level increases cadmium resistance through downregulation of Sp1-dependent expression of cadmium transporter ZIP8
Published June 12, 2008; doi: 10.1124/mol.108.046862 [Abstract] [PDF]  

10 June 2008

Gustav Akk, Ping Li, John Bracamontes, David E Reichert, Douglas F Covey, and Joseph H. Steinbach

Mutations of the GABA-A receptor 1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids
Published June 10, 2008; doi: 10.1124/mol.108.048520 [Abstract] [PDF]  

Aditi P Martin, Anna Miller, Luni Emdad, Mohammed Rahmani, Teneille Walker, Clint Mitchell, Michael P Hagan, Margaret A Park, Adly Yacoub, Paul B Fisher, Steven Grant, and Paul Dent

Lapatinib resistance in HCT116 cells is mediated by elevated MCL-1 expression, decreased BAK activation, and not by ERBB receptor mutation
Published June 10, 2008; doi: 10.1124/mol.108.047365 [Abstract] [PDF] [Data Supplement]  

6 June 2008

Rosalind Mann, Mark J. Wigglesworth, and Dan Donnelly

LIGAND-RECEPTOR INTERACTIONS AT THE PARATHYROID HORMONE (PTH) RECEPTORS: SUBTYPE BINDING SELECTIVITY IS MEDIATED VIA AN INTERACTION BETWEEN RESIDUE 23 ON THE LIGAND AND RESIDUE 41 ON THE RECEPTOR
Published June 6, 2008; doi: 10.1124/mol.108.048017 [Abstract] [PDF]  

5 June 2008

Sheryl A Flanagan, Christina M Krokosky, Sudha Mannava, Mikhail A Nikiforov, and Donna S Shewach

MLH1 Deficiency Enhances Radiosensitization with 5-Fluorodeoxyuridine by Increasing DNA Mismatches
Published June 5, 2008; doi: 10.1124/mol.107.043349 [Abstract] [PDF]  

4 June 2008

Lawrence S. Barak, Ali Salahpour, Xiaodong Zhang, Bernard Masri, Tatyana D. Sotnikova, Amy J. Ramsey, Jonathan D. Violin, Robert J. Lefkowitz, Marc G. Caron, and Raul R. Gainetdinov

Pharmacological Characterization of Membrane-Expressed Human Trace Amine Associated Receptor 1 (TAAR1) by a Bioluminescence Resonance Energy Transfer (BRET) cAMP Biosensor
Published June 4, 2008; doi: 10.1124/mol.108.048884 [Abstract] [PDF]  

Pierre-Alexandre Vidi, Benjamin R. Chemel, Chang-Deng Hu, and Val J. Watts

Ligand-Dependant Oligomerization of Dopamine D₂ and Adenosine A_2A Receptors in Living Neuronal Cells
Published June 4, 2008; doi: 10.1124/mol.108.047472 [Abstract] [PDF] [Data Supplement]  

Rama Panford-Walsh, Wibke Singer, Lukas Ruttiger, Saida Hadjab, Justin Tan, Hyun-Soon Geisler, Ulrike Zimmermann, Iris Kopschall, Karin Rohbock, Anna Vieljans, Elmar Oestreicher, and Marlies Knipper

Midazolam Reverses Salicylate Induced Changes in BDNF and Arg3.1 Expression: Implications for Tinnitus Perception and Auditory Plasticity
Published June 4, 2008; doi: 10.1124/mol.108.046375 [Abstract] [PDF]  

Rongbao Zhao, Andong Qiu, Eugenia Tsai, Michaela Jansen, Myles H. Akabas, and I. David Goldman

The Proton-Coupled Folate Transporter (PCFT): Impact on Pemetrexed Transport and on Antifolates Activities as Compared to the Reduced Folate Carrier
Published June 4, 2008; doi: 10.1124/mol.108.045443 [Abstract] [PDF]  

Yi-He Ling, Ruoping Lin, and Roman Perez-Soler

Erlotinib Induces Mitochondrial-Mediated Apoptosis in Human H3255 Non-Small Cell Lung Cancer Cells with EGFR^L858R Mutation through Mitochondrial Oxidative Phosphorylation-Dependent Activation of Bax and Bak
Published June 4, 2008; doi: 10.1124/mol.107.044396 [Abstract] [PDF] [Data Supplement]  

3 June 2008

Helen H. W. Chen, Im-sook Song, Anwar Hossain, Min-Koo Choi, Yoshiaki Yamane, Zheng D. Liang, Jia Lu, Lily Y Wu, Zahid Siddik, leo W. J. Klomp, Naramol Savaraj, and Macus T. Kuo

Elevated Glutathione Levels Confers Cellular Sensitization to Cisplatin Toxicity by Upregulation of Copper Transporter hCtr1
Published June 3, 2008; doi: 10.1124/mol.108.047969 [Abstract] [PDF]  

Ohad Mazor, Ofer Cohen, Chanoch Kronman, Lily Raveh, Dana Stein, Arie Ordentlich, and Avigdor Shafferman

Aging-Resistant Organophosphate Bioscavenger Based on PEGylated Phe338Ala Human Acetylcholinesterase
Published June 3, 2008; doi: 10.1124/mol.108.047449 [Abstract] [PDF]  

Julius Militante, Bei-Wen Ma, Gustav Akk, and Joseph H. Steinbach

Activation and block of the adult muscle-type nicotinic receptor by physostigmine: single-channel studies
Published June 3, 2008; doi: 10.1124/mol.108.047134 [Abstract] [PDF]  

Louis-Philippe Bernier, Ariel R. Ase, Xinkang Tong, Edith Hamel, Dominique Blais, Qi Zhao, Diomedes Logothetis, and Philippe Seguela

Direct modulation of P2X₁ receptor-channels by the lipid phosphatidylinositol 4,5-bisphosphate
Published June 3, 2008; doi: 10.1124/mol.108.047019 [Abstract] [PDF]  

Isabelle Bar, Pieter-Jan Guns, Jessica Metallo, Dorothee Cammarata, Francoise Wilkin, Jean-Marie Boeynaems, Hidde Bult, and Bernard Robaye

Knock-out mice reveal a role for P2Y₆ receptor in macrophages, endothelial cells and vascular smooth muscle cells
Published June 3, 2008; doi: 10.1124/mol.108.046904 [Abstract] [PDF]  

Michael H. Court, Suwagmani Hazarika, Soundararajan Krishnaswamy, Moshe Finel, and J. Andrew Williams

Novel polymorphic human UDP-glucuronosyltransferase (UGT) 2A3: Cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction
Published June 3, 2008; doi: 10.1124/mol.108.045500 [Abstract] [PDF]  

Laura Stanasila, Liliane Abuin, Julien Dey, and Susanna Cotecchia

DIFFERENT INTERNALIZATION PROPERTIES OF THE 1a AND 1b-ADRENERGIC RECEPTOR SUBYTPES: THE POTENTIAL ROLE OF RECEPTOR INTERACTION WITH ARRESTINS AND AP50
Published June 3, 2008; doi: 10.1124/mol.107.043422 [Abstract] [PDF] [Data Supplement]  

Stewart M Knoepp, Manpreet S Chahal, Yuhuan Xie, Zhihong Zhang, Daniel J Brauner, Mark A Hallman, Stephanie A Robinson, Shujie Han, Masaki Imai, Stephen Tomlinson, and Kathryn E Meier

Effects of active and inactive phospholipase D2 on signal transduction, adhesion, migration, invasion, and metastasis in EL4 lymphoma cells
Published June 3, 2008; doi: 10.1124/mol.107.040105 [Abstract] [PDF]  

29 May 2008

Adebowale Adebiyi, Elizabeth M McNally, and Jonathan H Jaggar

Sulfonylurea Receptor-Dependent and -Independent Pathways Mediate Vasodilation Induced by K_ATP Channel Openers
Published May 29, 2008; doi: 10.1124/mol.108.048165 [Abstract] [PDF]  

28 May 2008

Marina Galvez-Peralta, Nga T Dai, Dave A Loegering, Karen Flatten, Stephanie Safgren, Jill Wagner, Matthew M Ames, Larry M Karnitz, and Scott H Kaufmann

Overcoming S-Phase Checkpoint-Mediated Resistance: Sequence-Dependent Synergy of Gemcitabine and SN-38 In Human Carcinoma Cell Lines*
Published May 28, 2008; doi: 10.1124/mol.108.047787 [Abstract] [PDF] [Data Supplement]  

Christophe D Proulx, Brian J Holleran, Antony A Boucard, Emanuel Escher, Gaetan Guillemette, and Richard Leduc

Mutational analysis of the conserved Asp^2.50 and ERY motif reveals signaling bias of the urotensin II receptor
Published May 28, 2008; doi: 10.1124/mol.108.045054 [Abstract] [PDF]  

Huixia Zhang, Xiaohui Wu, Honggang Wang, Andrei M. Mikheev, Qingcheng Mao, and Jashvant D. Unadkat

Effect of pregnancy on cytochrome P450 3a and P-glycoprotein expression and activity in the mouse: mechanisms, tissue specificity, and time course
Published May 28, 2008; doi: 10.1124/mol.107.043851 [Abstract] [PDF]  

15 May 2008

Im-Sook Song, Helen H. W. Chen, Isamu Aiba, Anwar Hossain, Zheng D. Liang, Leo Klomp, and Macus Tien Kuo

Transcription Factor Sp1 Plays an Important Role in the Regulation of Copper Homeostasis in Mammalian Cells
Published May 15, 2008; doi: 10.1124/mol.108.046771 [Abstract] [PDF]  

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